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产品型号27651-3

品牌BPS Bioscience

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●Purchase●DescriptionSGI-1776isapotentATP-competitiveinhibitoroftheserine/threoninefamilyofPimkinase,anenzymeregulatingcellsurvival

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Description

SGI-1776 is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. Treatment with SGI-1776 induces apoptosis in CLL primary cell line.

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Synonyms

N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine

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