AR-42 (OSU-HDAC42) 返回列表页

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产品型号27603-2

品牌BPS Bioscience

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产品简介

●Purchase●DescriptionAR-42(alsoknownasOSU-HDAC42),aderivativeofhydroxamate-tetheredphenylbutyrateisabroad-spectrumdeacetylaseinhibitorofbothhistoneandnon-histoneproteins

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Description

AR-42 (also known as OSU-HDAC42), a derivative of hydroxamate-tethered phenylbutyrate is a broad-spectrum deacetylase inhibitor of both histone and non-histone proteins. AR-42 treatment induces histone hyperacetylation and p21WAF/CIP1 overexpression, inhibits gp130/Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells.

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Synonyms

OSU-HDAC42; N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide

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