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Zalcitabine

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产品型号7481-89-2

品       牌Chemleader

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所  在  地上海

更新时间:2024-05-23 17:33:02浏览次数:586次

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Zalcitabine;扎西他滨;7481-89-2
仅用于工业应用或科学研究,不可用于人类或动物的临床诊断或治疗,非药用.Zalcitabine (trade name Hivid) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). It is an antiviral pyrimidine nucleoside analogue effective against HIV replication. 2′,3′-Dideoxycytidine, when activated to its triphosphate, is incorporated into DNA by HIV-1 RT (HIV-1 reverse transcriptase), causing DNA chain termination and viral replication. Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. It is used as part of a combination regimen. Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events.

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