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仅用于工业应用或科学研究，不可用于人类或动物的临床诊断或治疗，非药用. Aflibercept （VEGF Trap） is a soluble decoy Rapidly and dose-dependently elevated BP in mice and markedly impaired endothelial-dependent relaxation （EDR） and resulted in NADPH oxidases 1 （NOX1）- and NADPH oxidases 4 （NOX4）-mediated generation of ROS, decreased the activation of protein kinase B （Akt） and endothelial nitric oxide synthase （eNOS） concurrently with a reduction in nitric oxide （NO） production and elevation of ET-1 levels in mouse aortas.