NLRP3 (D4D8T) Rabbit mAb

抗体名： NLRP3（D4D8T）兔单克隆抗体 浓度： 见优宁维 % 靶点： 见优宁维 宿主： Rabbit 用途范围： 详见说明书 ......

温馨提示:优宁维所有产品和服务仅用于科学研究,不用于临床等诊断及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 

反应性	H M
灵敏度	内源性
MW (kDa)	110
来源/同种型	兔 IgG

应用关键词:

• WB- 蛋白质印迹法
• IP-免疫沉淀法
• IHC-免疫组织化学法
• ChIP-染色质免疫沉淀法
• IF-免疫荧光法
• F-流式细胞术
• E-P-ELISA 肽

物种交叉反应性关键词:

• H-人
• M-小鼠
• R-大鼠
• Hm- 仓鼠
• Mk-猴
• Vir- 病毒
• Mi-水貂
• C-鸡
• Dm-黑腹果蝇
• X-爪蟾
• Z-斑马鱼
• B-牛
• DG-犬
• PG-猪
• Sc-酿酒酵母
• Ce-秀丽隐杆线虫
• Hr-马
• All-预期所有物种

background

The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) protein family is a diverse family of cytoplasmic innate immune receptors. They are characterized by the presence of an amino-terminal effector domain, usually a caspase activation and recruitment domain (CARD) or a pyrin domain (PYD), followed by a NACHT domain and a carboxyl group involved in the recognition of pathogen-associated molecular patterns (PAMPs) Terminal leucine-rich repeats (LRRs) (1). NLR proteins play various roles in the innate immune response, including detection of pathogens, transcriptional activation of proinflammatory cytokines through NF-κB, transcriptional activation of type I interferons through IRF, and formation of inflammasomes that activate inflammatory caspases (1-7 ).
NLRP3 is an inflammasome-forming NLR that activates caspase-1 to mature IL-1β and IL-18 (8). The NLRP3 inflammasome does not assemble until after a variety of microbial and endogenous stimuli, so it is unlikely that NLRP3 interacts directly with its activators (8). NLRP3 expression reaches highest levels in dendritic cells, monocytes and macrophages (9).

1. Elinav, E. et al. (2011) Immunity 34, 665-79.
2. Inohara, N. et al. (1999) J Biol Chem 274, 14560-7.
3. Ogura, Y. et al. (2001) J Biol Chem 276, 4812-8.
4. Sabbah, A. et al. (2009) Nat Immunol 10, 1073-80.
5. Mariathasan, S. et al. (2004) Nature 430, 213-8.
6. Agostini, L. et al. (2004) Immunity 20, 319-25.
7. Martinon, F. et al. (2002) Mol Cell 10, 417-26.
8. Franchi, L. et al. (2012) Nat Immunol 13, 325-32.
9. Guarda, G. et al. (2011) J Immunol 186, 2529-34.