热烈祝贺我司客户又一篇SCI文章被期刊收录

热烈祝贺我司客户又一篇SCI文章被期刊收录

祝贺我司客户的研究成果被期刊《Clinical Rheumatology》收录

该论文标题： Predictors of response to TNFα antagonist therapy in Chinese rheumatoid arthritis
Clinical Rheumatology

发表日期：July 2015, Volume 34

期刊号：Issue 7, pp 1203–1210

老师在论文后期编辑过程中与我们积极互动，信帆生物给予了支持，zui终顺利被《Clinical Rheumatology》录用。

 以下是老师论文中使用我司产品的截图


该论文中所使用的以下ELISA试剂盒均购自我司。

Human IL-34 ELISA KIT(Xinfan Biotechology Co.,Ltd,shanghai，China)

Human TNF-a  ELISA KIT(Xinfan Biotechology Co.,Ltd,shanghai，China)

Human IL-6 ELISA KIT(Xinfan Biotechology Co.,Ltd,shanghai，China)

Human IL-8 ELISA KIT(Xinfan Biotechology Co.,Ltd,shanghai，China)

Human MMP-3  ELISA KIT(Xinfan Biotechology Co.,Ltd,shanghai，China)

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《Clinical Rheumatology》期刊介绍：
Clinical Rheumatology is an international journal devoted to publishing in the English language original clinical investigation and research in the general field of rheumatology with accent on clinical aspects at postgraduate level. Studies carried out anywhere in the world will be considered the basic criterion for acceptance being the medical and scientific standard of the work described.

文章介绍

This study aimed to investigate the clinical, immunological, and radiologic predictors of response to tumor necrosis factor (TNF)-α antagonist therapy in Chinese rheumatoid arthritis (RA). Ninety RA patients were divided into two groups according to their responsiveness to TNF-α antagonist therapy at 1 month: group A (responders) and group B (non-responders). After 3 months of therapy, all the 90 patients were re-assessed and re-divided into another two groups: group C (responders) and group D (non-responders). Serum samples and clinical characteristics as well as radiographic features were collected at baseline, first month, and third month post-initial administration of TNF-α antagonist. Serum TNF-α, interleukin (IL)-6, IL-8, IL-34, and matrix metalloproteinase (MMP)-3 were measured by enzyme-linked immunosorbent assay (ELISA). Disease activity and Sharp score were evaluated. (1) Comparisons between groups A and B: subjects in group A showed a lower level of erythrocyte sedimentation rate (ESR) and a higher level of albumin (ALB) at baseline than that of group B (p < 0.05). The cutoff value of ALB for prediction was ≥34.9 g/l and that of ESR was ≤55.5 mm/h. (2) Comparisons between groups C and D: group C showed lower levels of ESR, health assessment questionnaire (HAQ), and IL-34 at baseline (p < 0.05). The threshold for prediction were as follows: ESR ≤60 mm/h, HAQ ≤1.3125, and IL-34 ≤194.12 pg/ml. (3) The serum cytokines were positively correlated with C-reactive protein (CRP) and disease activity index, while ALB was negatively correlated with CRP and disease activity. Baseline ALB ≥34.9 g/l or ESR ≤55.5 mm/h might predict a good response at 1-month treatment of TNF-α antagonist, while baseline ESR ≤60 mm/h, HAQ ≤1.3125, and IL-34 ≤194.12 pg/ml might predict a good response at 3-month treatment.

热烈祝贺我司客户又一篇SCI文章被期刊收录