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EMCS 异型双功能交联剂 55750-63-5
EMCS 异型双功能交联剂 55750-63-5
产品名称：EMCS
中文名称：6-(马来酰亚胺基)己酸琥珀酰亚胺酯
英文名称：6-Maleimidohexanoic acid N-hydroxysuccinimide ester
CAS #: 55750-63-5
简介：N-(e-Maleimidocaproyloxy)succinimide ester (EMCS) is a non-cleavable, water insoluble, hetero-bifunctional crosslinker that is commonly used to crosslink haptens to carrier proteins and en-zyme to antibody. The EMCS crosslinker spacer arm is longer than GMBS. The EMCS NHS es-ter and maleimide reactive groups react with amino and sulfhydryl moieties, respectively.
N-（e-maleimidocaproyloxy）琥珀酰亚胺酯（EMCS）是不可切割、异型双功能交联剂不溶于水，是的交联半抗原载体蛋白和抗体。EMCS交联剂间隔臂长于刺激。EMCS NHS ES TER和马来酰亚胺基团的活性氨基和巯基基团反应。
Application
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
一种异型双功能交联剂将延长间隔与胺和巯基反应。通常情况下，耦合初通过酰胺键在pH 7.5缓冲含有伯胺分子（6.5-8.5）耦合是通过硫醚键在pH 6.8缓冲含游离巯基的分子比（6.5-7.0）。用于偶联物和半抗原载体分子复合物的制备。包含9个原子链接器。一个扩展的脂肪间隔稳定的马来酰亚胺耦合相比，芳香间隔之前。
结构式：
外观：白色粉末
Molecular Weight: 308.3
分子式:C14H16N2O6
CAS #: 55750-63-5
溶解度：DMF
Spacer Length: 9.4 Å
Alternative Names: N-(epsilon-Malaimidocaproyloxy) succinimide
纯度：98%+
保存：-20℃
：西安瑞禧生物科技有限公司
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