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详细介绍
细胞细菌实时表型反应测量系统
细胞代谢和监测变得容易，我们的无标记多通道测定法以非凡的度实时测量细胞和病原体的特定代谢表型。
使用微量量热法实时监测生物膜代谢。
快速抗菌药敏测试
对抗生素功效的一次或多次测试的细菌反应的高灵敏度测量–监测生死的准确性和速度达到新水平。
- 实时直接代谢读数，无需标记或添加
- 表型反应可提供易感和耐药菌株的确切行为
- 快速检测时间可快速诊断
- 连续和定量可视化的杀菌和抑菌效果
- AST的多功能抗生素组合测试
Thermogram
calScreener™ raw data
Heat over time curve
Integrated data, equivalent to bacterial growth curve
Escherichia coli planktonic growth in Mueller Hinton media. Normalized data vs control.
calScreener measures the power produced from the sample in Joules per second or µW and gives a specific curve dependent on the specimen and the culture media. When calScreener data is integrated over time the heat over time curve matches the conventional density growth curves from which the growth parameters can be calculated. Parameters such as maximum growth rate (the slope of the log phase in h-1) and the total biomass of the culture (Peak power in µW).
我们地测量生与死
直接代谢读数–我们通过监测暴露于抗生素的细菌的代谢变化来衡量生命的特征，calScreener™是wei一可以做到这一点并提供生长动力学和长期细胞生存力读数的解决方案
定义有效的组合治疗
现有数量有限的抗菌剂，并且尚无用于组合疗法测试的商业解决方案。 我们将为组合测试设定新的金标准
高灵敏度-提供准确的数据
calScreener具有很高的灵敏度，并且可以连续监测暴露于抗生素的细菌的代谢反应
快速实时的响应
不到8小时的抗生素敏感性以及正确测量细胞对细菌的杀伤和抑制作用意味着没有因细胞碎片或裂解细胞引起的错误反应
P. aeruginosa
A. baumannii
P. aeruginosa and A. baumannii planktonic growth in Mueller Hinton media, same experimental conditions as for BMD.
The calScreener™ gives completely flexibility regarding the single or combo treatment, making AST most flexible and relevant.
In these graphs, it can be observed the lack of effect in the metabolism of the culture of the single antibiotic used. However, there is a clear synergistic effect when using the combination of antibiotics in the bacterial metabolism. Prolonged observation of the activity makes it possible to study re-growth, biofilm formation and late-stage survival of population subsets.
The bacterial species and strain give rise to unique metabolic thermograms
P. aeruginosa
A. baumannii
K. pneumoniae
E. coli
Bacterial planktonic growth in Mueller Hinton media, same experimental conditions as for BMD.
The unique heat flow footprint obtained in calScreener is dependent on the metabolism of the specimen, and this depends on the strain studied, as well as on the culture media and the availability of nutrients within it. calScreener can be employed for both gram-negative and gram-positive bacteria with equal sensitivity.
Multi-center clinical validation
Symcel aims to establish calScreener™ as a new diagnostic device for antibiotic susceptibility testing with key opinion leader labs around Europe during 2018-2020.
Symcel has received one of the largest Horizon 2020 grants ever awarded to a Swedish company, €3.6 million for three clinical studies in 5 different European labs. Read more about this exciting development here and please reach out if you are interested in discovering more.
P. aeruginosa
A. baumannii
P. aeruginosa and A. baumannii planktonic growth in Mueller Hinton media, same experimental conditions as for BMD.
The calScreener™ gives completely flexibility regarding the single or combo treatment, making AST most flexible and relevant.
In these graphs, it can be observed the lack of effect in the metabolism of the culture of the single antibiotic used. However, there is a clear synergistic effect when using the combination of antibiotics in the bacterial metabolism. Prolonged observation of the activity makes it possible to study re-growth, biofilm formation and late-stage survival of population subsets.
The bacterial species and strain give rise to unique metabolic thermograms
P. aeruginosa
A. baumannii
K. pneumoniae
E. coli
Bacterial planktonic growth in Mueller Hinton media, same experimental conditions as for BMD.
The unique heat flow footprint obtained in calScreener is dependent on the metabolism of the specimen, and this depends on the strain studied, as well as on the culture media and the availability of nutrients within it. calScreener can be employed for both gram-negative and gram-positive bacteria with equal sensitivity.
Multi-center clinical validation
Symcel aims to establish calScreener™ as a new diagnostic device for antibiotic susceptibility testing with key opinion leader labs around Europe during 2018-2020.
Symcel has received one of the largest Horizon 2020 grants ever awarded to a Swedish company, €3.6 million for three clinical studies in 5 different European labs. Read more about this exciting development here and please reach out if you are interested in discovering more.
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