3D器官模拟芯片,HUMIMIC Chip 2/3/4-现货,HUMIMIC Chip2,HUMIMIC Chip3, HUMIMIC  chip4

授权代理，现货供应，

类器官模拟

3D微流体类器官模拟系统，2009年起担任人体器官芯片系统及微流体专家 。我们的使命: 提高对药物 安全性 & 有效性 的预测通过器官芯片 (MOC) 检测.
主要用途：细胞组织毒理学测试，生物标记发现、神经，免疫，代谢系统靶向药物研发、癌症个人化药物开发、早期临床药代动力学数据提供，体外活体组织培养等。
产品特点：

1.SEED种植

•任何细胞都能轻松的种植在开放式的培养板上。
 •广泛的培养形式选择，包括商业植入物，器官切片，3D基质和凝胶，组织特异性支架，无支架培养
   •容易定制或验证细胞/组织模型的加载系统包括MucilAir™,EpiSkin™和更多其他系统
2.CULTURE培养

•可编程应用流体学。器官内流量可调，优化氧气，营养和机械力

 •可方便地优化各器官间的流速，以实现的平台药动学 •媒介变化迅速且容易实现

3.DOSE给药 

•介入生物制剂(肽、蛋白质)、小分子、激素等

•基因编辑(CRISPR, Talen, ZFN)
               •引入免疫细胞(如细胞毒性T细胞、CAR-T细胞、NK细胞等)进行免疫分析和观察 
               •无PDMS组件，大限度减少非特定绑定干扰

  4.ANALYZE 分析 

•简单的(重复的)介质取样用于生物标志物分析(LC-MS, ELISA, multiplex)
            •可移动支架允许对微组织进行quan方位的分析组学方法
             •组织模拟可用于成像，以可视化细胞形态、细胞迁移和蛋白标记物定位
应用领域：

生物工程学与3D细胞培养

动物实验替代方案

神经，代谢系统靶向药物研发

个人化药物研发

在培养皿中临床试验

药物，烟草，化妆品，化学行业监管测试免疫

HUMIMIC Chips – Superpowers for Superb Insights

The success of any mission depends on having the right equipment. We offer chips that are perfectly tailored to your needs and your HUMIMIC Control Units. The choice of tissue source is yours: Regardless of whether you are using cell lines, primary cells, biopsies, tissue sections, or commercially available models, HUMIMIC chips provide a reliable platform for all your experiments. Interested in working with iPSCs? You can conveniently combine HUMIMIC iPSCs with HUMIMIC chips.

HUMIMIC Chip2

HUMIMIC Chip2

The HUMIMC Chip2 allows the simultaneous culture of two different organ models. Cells and tissues can be used to emulate biological barriers like the intestine, lung or skin, as well as to grow spheroidal and matrix-supported cultures for mimicking the three-dimensional environment of organs like the liver.

Product description

The organ models are connected by microfluidic channels. An on-chip pump enables a near lifelike nutrient and oxygen supply to the cells. This allows for detailed studies of distribution and metabolization of various substances like drugs, cosmetics, chemicals, and food additives enabling the prediction of substance effects.The HUMIMIC Chip2 is designed for use with non-invasive in-process controls like fluorescence microscopy and other optical methods .

A control unit like the HUMIMIC Starter is necessary to operate the HUMIMIC Chip2.

Features

• Efficient lifelike tissue nutrition
• Flexible combination of different tissues
• Compatible with different types of cell culture (primary cells, iPS-based models, biopsies)
• Long-term performance
• Physiological shear stress applicable
• Rapid prototyping for specific customer needs

HUMIMIC Chip3

HUMIMIC Chip3 und HUMIMIC Chip3plus

The HUMIMIC Chip3 is designed for the simultaneous c*tion of up to three organ models in a common microfluidic circuit. The HUMIMIC Chip3 und HUMIMIC Chip3plus have all the advantages as the HUMIMIC Chip2 while allowing the culture of an additional organ model.

Product description

The HUMIMIC Chip3 and Chip3plus gives you additional flexibility when selection your cell cultures due to its tailored design approach featuring organ compartments of varying size. A control unit like the HUMIMIC Starter is necessary to operate the HUMIMIC Chip3.

Features

• Efficient, lifelike nutrition of up to three organ models
• Flexible combination of different tissues
• Compatible with different types of cell cultures (primary cells, iPS-based models, biopsies)
• Long-term performance
• Physiological shear stress applicable
• Rapid prototyping for specific customer needs

HUMIMIC Chip4

HUMIMIC Chip4

The HUMIMIC Chip 4 enables easy integration of up to four different organ models, e. g. a combination of intestine, liver, kidney and neuronal tissue in one system.

Product description

The PBPK-compliant design allows for quantitative in vitro to in vivo extrapolation. The HUMIMIC Chip 4 uses two separate microfluidic circuits to model processes like excretion and reabsorption of various substances in the kidney model.

Features

• Efficient, lifelike tissue nutrition of up to four organ models
• Supports relevant PK/PD modeling for quantitative in vitro to in vivo extrapolation and determination of ADME profiles (absorption, distribution, metabolism and excretion)
• Long-term repeated performance
• Physiological shear stress applicable
• Enables multi-organ disease modelling

HUMIMIC Chip XX/XY

HUMIMIC ChipXX /ChipXY

HUMIMIC ChipXX and HUMIMIC ChipXY will be our most potent products among our Multi-Organ-Chips. They will reproduce a systemic model of the female and male body, respectively. HUMIMIC ChipXX und HUMIMIC ChipXY have the power to model human physiology thereby generating highly predictive data sets. (In Development)

Product description

Establishing personalized disease models on these Chips will ultimately lead to a “Patient-on-a-Chip”. Drugs can be tested on this chip before being administered to patients in order to gain information about efficacy and side effects. Thus, HUMIMIC XX and HUMIMC XY pave the way to personalized medicine approaches.

Features

• “Patient-on-a-Chip” system with high physiological relevance
• Will be able to generate data previously only accessible through clinical trials (phase I and II)
• Will reduce animal testing on a large scale