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详细介绍
OsteoGen3D灌注生物反应器系统
OsteoGen生物反应器通过圆筒支架灌注接种细胞。应用范围包括细胞功能研究、组织工程构建物生长和发育、药物和再生医学测试。目前研究人员正在利用这些系统在广泛的范围内开展研究领域，包括：
- 骨髓干细胞表型研究
- 骨髓基质干细胞矿物质沉积
OsteoGen提供了一个生理支持系统，改善了3D环境中的细胞生长和代谢条件。系统通过反馈控制再现了生理刺激参数。灵活的硬件和计算机控制系统允许各种各样的自动化实验步骤，具有不同程度的复杂性（压力幅度和频率），并可以容纳10 mm长度的支架。OsteoGen系统可容纳多达12个样品，样品之间相互独立，样品同时经受灌注循环。灌注泵可以提供低至0.06 mL/min的流量。
应用领域：矿化研究和骨组织工程。
OsteoGen: Perfusion Bioreactor Systems
BISS's OsteoGen bioreactors impart perfusion through cell seeded cylindrical scaffolds. Applications include investigating cell function, modulating the growth and development of engineered tissues, or acting as a test bed for drug and regenerative medicine technologies. Researchers are currently utilizing these systems in a wide range of research areas including:
- Bone stem cell phenotype research
- Mineral deposition of marrowstromal cells
1O OsteoGen
The 1O system has been designed as a single sample bioreactor system that is able to support a wide range of cell and tissue growth experiments. This chamber can accommodate a single sample with a maximum size of 10 mm diameter x 10 mm thick. Optional features such as: transducers, non-contact micrometers, pressure sensors, etc., and/or modules to customize the instrument to specific needs can be added to accommodate the research application.
12O OsteoGen
The 12O system has been designed as a single sample multi-chamber bioreactor system that is able to support a wide range of cell and tissue growth experiments via user defined stimulation protocols. This chamber can accommodate a single sample with a maximum size of 10 mm diameter x 10 mm thick. A custom manifold integrates up to 12 chambers with individual flow loops. Optional features such as; transducers, non-contact micrometers, pressure sensors, etc., and/or modules to customize the instrument to specific needs can be added to accommodate the research application.
BONE
Key: S=Standard, A=Available, - = not available
| CHAMBERS | 1O | 12O |
|---|---|---|
| Individual growth chamber | S | S |
| 12 parallel growth chambers | - | A |
| Max construct size: 6 mm diameter by 10 mm long | S | S |
| STIMULATION | ||
|---|---|---|
| Pulsatile fluid flow stimulator | A | A |
| CONTROLS | ||
|---|---|---|
| Controller software, computer, and monitor | - | - |
| Power supplies and cabling | - | - |
| Mean flow control | A | A |
| Dynamic flow control | - | - |
| TISSUE MONITORING | ||
|---|---|---|
| Non-contact flow sensors | A | A |
| Catheter pressure transducers | A | A |
| ACCESSORIES | ||
|---|---|---|
| Media reservoir | S | S |
| Incubator | A | A |
| BENEFITS | ||
|---|---|---|
| All-autoclavable components | S | S |
| Excellent sample access | S | S |
| Medium change without opening chamber via luer fittings | S | S |
| Increased sterility with fast and clean sample change and access | S | S |
| Lightweight design for easy handling | S | S |
| Easily cleaned surface finishes | S | S |
| Compact design for fit in standard incubators | S | S |
| 100% satisfaction guaranteed warranty | S | S |
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