 |
上海源叶生物科技有限公司
主营产品： S30260异硫氰酸胍,30259盐酸胍,嗜热菌蛋白酶 |
15
联系电话
15921386130
公司信息
- 联系人：
- 何小姐
- 电话：
- 86-021-61559134
- 手机：
- 15921386130
- 传真：
- 86-021-55068248
- 地址：
- 上海市松江区长塔路465号6幢
- 邮编：
- 200433
- 网址：
- www.shyuanye.com
S80047
| 参考价 | 面议 |
具体成交价以合同协议为准
- 型号
- 品牌
- 厂商性质 生产商
- 所在地
更新时间：2024-07-03 19:18:33浏览次数：160
联系我们时请说明是化工仪器网上看到的信息，谢谢!
- 提示：详情请下载说明书。
- 产品描述： Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM
- 靶点： IC50: 14 nM (Axl kinase)
- 体内研究： Bemcentinib (R428) (125 mg/kg, p.o.) significantly blocks MDA-MB-231-luc-D3H2LN metastases development in two independent mouse models of breast cancer dissemination, suppresses both tumor angiogenesis and vascular endothelial growth factor (VEGF)-induced corneal neovascularization in vivo. Bemcentinib (R428) (75 mg/kg/day, 25 mg/kg twice daily, p.o.) makes mice keep on a high-fat diet resulted in significantly reduced weight gain and subcutaneous and gonadal fat mass
- 参考文献：
1. Sensi M, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011 Dec;131(12):2448-57. 2. Hollａnd SJ, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54. 3. Lijnen HR, et al. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther. 2011 May;337(2):457-64.
- 溶解度： DMSO : 25 mg/mL (49.34 mM; ultrasonic and warming and heat to 60°C)
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 1.974 ml 9.869 ml 19.738 ml 5 mM 0.395 ml 1.974 ml 3.948 ml 10 mM 0.197 ml 0.987 ml 1.974 ml 50 mM 0.039 ml 0.197 ml 0.395 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的性，仅供客户参考交流研究之用。
