HM30181;HM30181A Encequidar
- 公司名称 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型号 HM30181;HM30181A
- 产地
- 厂商性质 生产厂家
- 更新时间 2019/7/11 13:47:45
- 访问次数 736
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MedChemExpress (MCE) 专注于为科学家提供高品质的生物活性小分子化合物，化合物库及各类试剂盒，总部位于美国新泽西。
• MedChemExpress (MCE) 产品作用于 20 多个热门信号通路及研究领域的300多个细分靶点，拥有 10000 特异性抑制剂、激动剂，以及 50 活性化合物筛选库；
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抑制剂，调节剂，API，天然产物，各种类型化合物库
| 供货周期 | 现货 | 规格 | 10 mM * 1 mL；5 mg；10 mg |
|---|---|---|---|
| 货号 | HY-13646 | 应用领域 | 生物产业 |
Encequidar
产品活性：Encequidar (HM30181) 是一种有效的选择性的P-glycoprotein抑制剂。
研究领域：Membrane Transporter/Ion Channel
作用靶点：P-glycoprotein
In Vitro: Encequidar (HM30181) is shown to be approximately equipotent with the reference Pgp inhibitor tariquidar in inhibiting rhodamine 123 efflux from CCRF-CEM T cells (IC50, tariquidar: 8.2±2.0 nM, Encequidar (HM30181): 13.1±2.3 nM) . Encequidar (HM30181) shows a high selectivity for mP-gp and its potency is 20-50 times higher than that of tariquitar, another third generation P-gp inhibitor.
In Vivo: PET scans with the Pgp substrate (R)-[11C]verapamil in FVB wild-type mice pretreated i.v. with Encequidar (HM30181) (10 or 21 mg/kg) failes to show significant increases in (R)-[11C]verapamil brain uptake compared with vehicle treated animals. Encequidar (HM30181) inhibits P-gp mainly in the intestinal endothelium, which can be beneficial because pan-inhibition of P-gp, particularly in the brain, could lead to detrimental adverse events. Encequidar (HM30181) increases the oral bioavailability of co-administered paclitaxel by more than 12 times in rats.
相关产品：Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Elacridar | Valspodar | Zosuquidar trihydrochloride | Tariquidar | Risperidone | Sinapine thiocyanate | Piperine | (20S)-Protopanaxadiol | Dofequidar fumarate | NSC23925 | Alisol F | Zamicastat | P-gp modulator 1 | Polyoxyethylene stearate | Biricodar | Encequidar mesylate | MCI826 | P-gp inhibitor 1 | Reversan
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