324759-76-4 CCT020312
- 公司名称 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型号 324759-76-4
- 产地
- 厂商性质 生产厂家
- 更新时间 2019/7/9 15:53:04
- 访问次数 437
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供货周期 | 现货 | 规格 | 10 mM * 1 mL;5 mg;10 mg |
---|---|---|---|
货号 | HY-119240 | 应用领域 | 生物产业 |
CCT020312
产品活性:CCT020312能提供有效的、具有真核起始因子 2 激酶 3 (EIF2AK3) 选择性的增殖控制,同时也是 RNA 样内质网激酶 (PERK) 的激动剂。
研究领域:Cell Cycle/DNA Damage
作用靶点:PERK | Eukaryotic Initiation Factor (eIF)
In Vitro: Treatment of HT29 cells with CCT020312 for 24 hours reveals a concentration-dependent loss of P-S608-pRB signal, with a linear response between 1.8 and 6.1 μM. CCT020312 treatment effectively inhibits cell proliferation (as measured at 96 hours) even if treatment is for 2 hours only with subsequent compound washout, indicating that CCT020312 is capable of eliciting durable rather than transient cytostasis. Treatment of HT29 cells with 10 μM CCT020312 for 24 hours reduces the amount of the G1/S cyclins D1, D2, E and A as well as the CDK catalytic subunit CDK2 and increased the level of the CDK inhibitor p27KIP1 present in such cells.
In Vivo: Treatment of mice with the PERK activator CCT020312 leads to increased levels of phosphorylated PERK and NRF2 in brain homogenates.
相关产品:Kinase Inhibitor Library | Anti-Cancer Compound Library | Cell Cycle/DNA Damage Compound Library | Bioactive Compound Library Plus | Silvestrol | GSK2606414 | GSK2656157 | 4EGI-1 | ISRIB trans-isomer | GCN2iB | 4E1RCat | 4E2RCat | Briciclib | SBI-0640756 | eIF4A3-IN-2