rs RS 504393
- 公司名称 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型号 rs
- 产地
- 厂商性质 生产厂家
- 更新时间 2019/7/4 8:54:26
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MedChemExpress (MCE) 专注于为科学家提供高品质的生物活性小分子化合物，化合物库及各类试剂盒，总部位于美国新泽西。
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抑制剂，调节剂，API，天然产物，各种类型化合物库
| 供货周期 | 现货 | 规格 | 10 mM * 1 mL；5 mg；10 mg |
|---|---|---|---|
| 货号 | HY-15418 | 应用领域 | 生物产业 |
RS 504393
产品活性：RS 504393 是一种选择性的 CCR2 拮抗剂，作用于人重组 CCR2 和 CCR1 受体，IC50 值分别为 89 nM 和 > 100 μM。
研究领域：GPCR/G Protein | Immunology/Inflammation
作用靶点：CCR
In Vitro: RS 504393 inhibits the MCP-1-induced chemotaxis with an IC50 of 330 nM. RS 504393 treatment suppresses allergen induced β-hexosaminidase release significantly. Without allergen priming, MCP-1 induces mast cell degranulation, which is completely suppressed by RS 504393.
In Vivo: RS504393 (0.3-3 μg) with CCL2 progressively blocks thermal hyperalgesia dose-dependently in mice. RS 504393 (5 mg/kg, i.v.) supresses the elevated numbers of leukocytes and increased total protein content in BALF induced by The LPS. RS504393 significantly down regulates the LPS-induced elevation of IL-1β, PAI-1 mRNA and protein expressions. RS504393 significantly suppresses induced lung edema, protein-rich fluid, polymorphonuclear accumulation and bronchial wall thickening induced by LPS. RS-504393 significantly reduces renal pathology, especially the extensive interstitial fibrosis mediated by decrease in type I collagen synthesis in a UUO model.
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