BioDent活体骨骼质量测试分析仪系统

BioDent™

Why do I need BioDent?

Direct Measurements BioDent allows for direct measurement, rather than a surrogate, of tissue function in a clinically relevant way.	Ease of Use No extensive technical background is necessary to learn how to use BioDent.	First & Only Solution BioDent is the first device of its kind. Direct, clinically relevant measurement of tissues is providing never before available insight into tissue function.

It is generally understood that material properties are an important contributor to tissue and biomaterial health. However, no instruments have been available to easily measure these properties in the laboratory in a way that can translate into clinical practice – often causing this important information to be excluded from research.  Also, no tools have previously been available to measure tissue material properties in vivo – resulting in frequent exclusion of their evaluation in life science research altogether.

BioDent™ is the first and only solution for life science researchers to easily and directly obtain clinically measurable material properties.

What does BioDent™ l me?

BioDent™ outputs have been used to describe the mechanical effect of tissue health, treatment, and disease. Hard and soft tissues are comprised of many material components that come together to give tissue its desired function. Understanding how tissue function changes due to treatment or disease opens a new perspective on health.

Depending on your setup, BioDent™ can probe across the micrometer to millimeter length scale in order to provide a robust measure across all material components in the tissue or biomaterial. BioDent™ can also provide previously impossible direct, in vivo measures of tissue function – clinically measurable material properties.

How easy is it to use BioDent™?
Like every scientific instrument there is some training required before using BioDent™, however unlike many scientific instruments, no extensive technical background is necessary. Active Life Scientific, Inc. provides all training material with the instrument, sufficient to get a non-technical scientist up and running in a few hours or less.  For Advanced Users, certain BioDent™ configurations offer access to waveform control inputs and data analysis outputs through layered interfaces.
	In just 30 seconds, a trained user can perform a mechanical test.   Step 1: Attach and position sample. Step 2: Lower BioDent probe to sample. Step 3: Click “measure” to gather data in real time.

OsteoProbe骨质量测试分析仪系统

活体在体非破坏性地测量两种模式下测试分析活体内骨骼组织的硬度、弹性系数、zui大压痕距离与压痕距离增加值等机械特性（其中压痕距离增加值表示骨折或其他病变组织与正常组织的差异）、测试分析骨内之矿物质含量及分析骨骼微结构，这对于阐明骨科疾病，比如骨质疏松症、关节炎等疾病的发病机制、揭示正常生命机体生长、发育和衰老的机理和自然规律、对于阐明机体骨组织疾病的发病机理及提供诊断和治疗的基本原理均都是具有极其重要的理论和现实意义,以便更好的为临床服务。

OsteoProbe®

Quick. Accurate. Innovative. In Vivo.

The first and only medical device for direct measurement of bone material quality in vivo. Empowering physicians with the ability to measure the material aspects of bone quality for the first time.

View Publications

What is OsteoProbe® ?

OsteoProbe® (for research use only in the United States) is a portable handheld microindenter that measures the ability of bone material to resist indentation. Unlike radiological methods (X-ray, DXA and CT) that measure bone mineral density and bone mineral structure, OsteoProbe® measures bone material quaility; an independent component of bone strength.

OsteoProbe® uses Reference Point Indentation (RPI) technology to investigate the bone material’s ability to resist a localized force (resist separation of mineralized collagen fibrils). This is quantified by the Bone Material Strength index (BMSi).

Direct Measurements

Every measurement taken is recorded in OsteoProbe’s software, providing the most accurate data.

Ease of Use

OsteoProbe can be used by a physician, nurse, or technician after brief training.

First & Only Solution

The first and only medical device(approved in Europe) for direct measurement of bone material qualityin vivo.

Related Literature

Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density

Journal of Clinical Endocrinology & Metabolism, Dr. Socrates Papapoulos et al, 2015

Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis

Journal of Bone and Mineral Research, Dr. Adolfo Diez Perez et al, 2015

In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes

Journal of Bone and Mineral Research, Dr. Sundeep Khosla et al, 2013

What does OsteoProbe® measure?

OsteoProbe® measures and quantifies material aspects of bone, providing a clearer understanding of Bone Quality. Bone is composed of mineral and organic (Bone Glue) building blocks. Current clinical techniques provide detailed information about the mineral aspects of bone but there limited techniques to provide information about the organic aspects and function. Learn more about Bone Quality.

In the clinical setting, material properties of Bone Quality have been ignored due to the lack of a method for in vivo measurement. Reference Point Indentation (RPI) is a technique bringing change to the current situation in a clinical research setting. RPI enables physicians and researchers to have an in vivo method for directly measuring material aspects of bone quality. With RPI, physicians and researchers can measure and monitor changes in the material quality of bone.

Related Literature

In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes

Journal of Bone and Mineral Research, Dr. Sundeep Khosla et al, 2013

Measuring Bone Quality

Current Rheumatology Reports, Diez-Pérez, A. et al, 2013

Identifying novel clinical surrogates to assess human bone fracture toughness

Current Rheumatology Reports, Nyman, J. S. et al, 2015

The Contribution of the Extracellular Matrix to the Fracture Resistance of Bone

Curr Osteoporos Rep., Nyman, J. S. et al, 2012

How does OsteoProbe® work?

OsteoProbe® uses Reference Point Indentation (RPI) technology to measure bone material’s ability to resist a localized force. Utilizing a probe specifically designed for percutaneous measurements, OsteoProbe penetrates soft tissue down and touches the bone surface, establishing a local reference point. Once actuated, OsteoProbe measures the bone’s resistance to force and outputs a Bone Material Strength index (BMSi) or Bone Score.

Learn more about how OsteoProbe® works.

Related Literature

A new device for performing reference point indentation without a reference probe

Review of Scientific Instruments, Dr. Paul Hansma, 2012

Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength

Journal of Medical Devices, Dr. Paul Hansma, 2013

How easy to use is OsteoProbe® ?

OsteoProbe® was designed with the physician in mind.

OsteoProbe® allows quick and easy measurement of bone material quality data with minimal training.

Learn more about using OsteoProbe®.

Related Literature

In vivo research from Hospital del Mar, Spain by Prof. Adolfo Diez-Perez

YouTube, Prof. Adolfo Diez-Perez, 2011

Osteoprobe Usage on Simulated Soft Tissue by the Hansma Lab

Vimeo, Dr. Paul Hansma, 2013

OsteoProbe®  built to inspire discoveries that benefit human health.

OsteoProbe®  was invented to empower physicians and researchers with the tool they need to discover how genetics, disease, diet, exercise, and other triggers affect the quality of the bone tissue.

The bigger picture is that Reference Point Indentation was invented to enable scientists to discover better treatments, medical professionals can deliver better results, and people can live actively throughout their entire life. Learn more about the invention.

Related Literature

In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes

Journal of Bone and Mineral Research, Dr. Sundeep Khosla el al, 2013

Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis

Journal of Bone and Mineral Research, Dr. Adolfo Diez Perez el al, 2015

Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density

Journal of Clinical Endocrinology & Metabolism, Dr. Socrates Papapoulos et al, 2015

Are the High Hip Fracture Rates Among Norwegian Women Explained by Impaired Bone Material Properties?

Journal of Bone and Mineral Research, Dr. Erik Eriksen et al, 2015

OsteoProbe® Publications

• Are the High Hip Fracture Rates Among Norwegian Women Explained by Impaired Bone Material Properties?
  Journal of Bone and Mineral Research, Dr. Erik Eriksen et al, 2015
• Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density
  Journal of Clinical Endocrinology & Metabolism, Dr. Socrates Papapoulos et al, 2015
• Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis
  Journal of Bone and Mineral Research, Dr. Adolfo Diez Perez et al, 2015
• Study of indentation of a sample equine bone using finite element simulation and single cycle reference point indentation
  Journal of the Mechanical Behavior of Biomedical Materials, Dr. Henry Yang et al, 2015
• In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes
  Journal of Bone and Mineral Research, Dr. Sundeep Khosla et al, 2013
• Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength
  Journal of Medical Devices, Dr. Paul Hansma, 2013
• A new device for performing reference point indentation without a reference probe
  Review of Scientific Instruments, Dr. Paul Hansma, 2012