MTX007-00100 MT7 – Muscarinic Toxin 7(毒蕈碱毒素7)
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- 型号 MTX007-00100
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MT7 – Muscarinic Toxin 7(毒蕈碱毒素7)
Blocker of M1-subtype of muscarinic receptor
毒蕈碱型受体M1亚型阻断剂
Muscarinic toxin 7 (MT7 – m1-toxin 1) has been isolated from the venom of the green mamba (Dendroaspis Angusticeps). MT7 potently blocks M1-subtype of muscarinic acetylcholine receptors at a subnanomolar affintiy. Muscarinic acetylcholine receptors are G-protein coupled receptors that mediate the metabotropic effects of acetylcholine. M1-type muscarinic acetylcholine receptors are well known therapeutic targets to improve cognitive functions in patients with Alzheimer disease. Contrary to many ligands that target mAChRs (pirenzepine, carbamoylcholine chloride, 4-DAMP or atropine), MT7 is the most selective M1-subtype antagonist as it is about 10,000 times more selective for M1-subtype than other subtypes. MT7 toxin is an ideal tool to identify the muscarinic receptor subtype expression in tissues for example. MT7 toxinbelongs to the three finger toxin family such as rho-Da1a.
MT7 – Muscarinic Toxin 7(毒蕈碱毒素7)技术资料
氨基酸序列:
LTC3VKSNSIWFPTSEDC17PDGQNLC24FKRWQYISPRMYDFTRGC42AATC46PKAEYRDVINC57C58GTDKC63NK
二硫键: Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, Cys58-Cys63
长度 (aa): 65
分子式:C322H484N90O98S9
分子量:7472.53 Da
外观:White lyophilized solid
可溶性:water and saline buffer
CAS 号:not available
来源:Synthetic
纯度:> 98%
产品信息
货号 | 名称 | 规格 |
MTX007-00100 | MT7 – Muscarinic Toxin 7(毒蕈碱毒素7) | 50ug/100ug/5×10ug |
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