PP2A Phospho （pY307）

A synthetic phospho-peptide corresponding to residues surrounding Tyr307 of human PP2A was used as immunogen. The antibody only detects PP2A phosphorylated on Tyrosine 307. Predicted to cross-react with mouse, rat, bovine and pig, based on sequence homology.

50 mM Tris-Glycine （pH 7.4）, 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

PPP2CA, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Replication protein C

1. Janssens, V. and J. Goris. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353: 417
2. Zabrocki, P., et al. Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Mol. Microbiol. 43: 835
3. Milward, T.A., et al. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24: 186
4. Chen, J., et al. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257: 1261-1264 （1992）.
 

1. Huang Y, Huang K, Boskovic G, et al, Proteomic and genomic analysis of PITX2 interacting and regulating networks ,FEBS Letters 583 （2009） 638-642
[Application: IP （YB-1） WB （1848-1） ]
2. Yu CF, Han WL, Shi TP, et al, PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway ,Cellular Signalling 20 （2008） 2208-2220
[Application: IP ]
3. Ulloa A, Gonzales AL, Zhong M, et al, Reduction in TRPC4 expression specifically attenuates G-protein coupled receptor-stimulated increases in intracellular calcium in human myometrial cells ,Cell Calcium 46 （2009） 73-84
[Application: WB ]
4. Mizutani T, Fukushi S, Saijo M, et al, Regulation of p90RSK phosphorylation by SARS-CoV infection in Vero E6 cells ,FEBS Letters 580 （2006） 1417-1424
[Application: WB ]
5. Westin JE, Vercammen L, Strome EM, et al, Spatiotemporal Pattern of Striatal ERK1/2 Phosphorylation in a Rat Model of L-DOPA-Induced Dyskinesia and the Role of Dopamine D1 Receptors ,BIOL PSYCHIATRY 62 （2007） 800-810
[Application: IHC ]
6. Onishi A, Chen QM, Humtsoe JO, et al, STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells ,Experimental cellreseach 314 （2008） 377-386
[Application: WB ]
7. N.Unsain, N.Nunez, A.Anastasia, et al, Status Epilepticus Induces a TrkB to p75 Neurotrophin Receptor Switch and Increases Brain-derived Neurotrophic Factor Interaction With p75 Neurotrophin Receptro: An Initial Event in Neuronal Injury Induction ,Neuroscience 154 （2008） 978-993
[Application: WB ]
8. Chun KR, Bae EM, Kim JK, et al, Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein （MRP） affects transmigration in activated RAW264.7 cells ,Cellular Immunology 256 （2009） 92-98
[Application: FC ]
9. Ramel D, Lagarrigue F, Dupuis-Coronas S, et al, PtdIns5P protects Akt from dephosphorylation through PP2A inhibition ,Biochem Biophys Res Commun. 387 （2009） 127-131
[Application: WB ]
10. Kim SH, Markham JA, Weiler IJ, et al, Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome ,Proceedings of the National Academy of Sciences 105 （2008） 4429-4434
[Application: WB ]
11. Barreyro FJ, Kobayashi S, Bronk SF, et al, Transcriptional Regulation of Bim by FoxO3A Mediates Hepatocyte Lipoapoptosis ,The Journal of Biological Chemistry 282 （2007） 27141-27154
[Application: WB ]
12. Chen L, Liu L, Yin J, et al, Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A, 5, leading to activation of MAPK pathway ,The International Journal of Biochemistry & Cell Biology 41 （2009） 1284-1295
[Application: WB ]
13. Shay KP, Hagen TM, PP2A （pY307） ,Biogerontology 10 （2009） 443-456
[Application: WB]