Anti-BMPR1B抗体,骨形态发生蛋白受体1B抗体
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英文名称phospho-B-Raf (Ser444)
中文名称 Anti-BMPR1B抗体,骨形态发生蛋白受体1B抗体
别 名94 kDa B raf protein; B raf 1; B Raf proto oncogene serine threonine protein kinase; BRAF 1; Braf; BRAF1; cRmil; MGC126806; MGC138284; Murine sarcoma viral (v-raf) oncogene homolog B1; Murine sarcoma viral v raf oncogene homolog B1; p94; RAFB 1; RAFB1; v raf murine sarcoma viral oncogene homolog B1; FLJ95109; BRAF_HUMAN.
规格0.1ml
产品类型磷酸化抗体
研究领域肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit,
产品应用WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量94kDa
细胞定位细胞核 细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human B-Raf around the phosphorylation site of Ser444
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
Anti-BMPR1B抗体,骨形态发生蛋白受体1B抗体产品介绍background:
The Raf kinases are important intermediates in signal transduction. Raf protein family members, including A Raf and B Raf, have intrinsic serine/threonine kinase activity. Interaction between Ras proteins and Raf proteins results in Raf-mediated phosphorylation and activation of MEK (also known as MAP kinase kinase). Defects in BRAF are involved in a wide range of cancers. B-Raf is a serine/threonine protein kinase that acts as a signal transducer from membrane-associated receptors to nuclear transcription factors. 1 BRAF is important for the regulation of cell proliferation and determination of cell fate during embryogenesis. BRAF acts downstream of Ras and upstream of MEK in the Ras-Raf-MEK-ERK signal transduction pathway, which is a conserved RAS-activated protein kinase cascade that regulates cell growth, proliferation, and differentiation in response to growth factors, cytokines, and hormones.
Function:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.
Subunit:
Monomer. Homodimer. Heterodimerizes with RAF1, and the heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers. Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the heterodimer by phosphorylating BRAF at Thr-753. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts with RIT1. Interacts (via N-terminus) with RGS14 (via RBD domains); the interaction mediates the formation of a ternary complex with RAF1, a ternary complex inhibited by GNAI1 (By similarity). Interacts with DGKH.
Subcellular Location:
Nucleus. Cytoplasm. Cell membrane.
Tissue Specificity:
Brain and testis.
Post-translational modifications:
Phosphorylation at Ser-365 by SGK1 inhibits its activity.
Methylation at Arg-671 decreases stability and kinase activity.
Ubiquitinated by RNF149; which leads to proteasomal degradation.
DISEASE:
Note=Defects in BRAF are found in a wide range of cancers.
Defects in BRAF may be a cause of colorectal cancer (CRC) [MIM:114500].
Defects in BRAF are involved in lung cancer (LNCR) [MIM:211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Defects in BRAF are involved in non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
Defects in BRAF are the cause of Noonan syndrome type 7 (NS7) [MIM:613706]. Noonan syndrome is a disorder characterized by facial dysmorphic features such as hyperorism, a downward eyeslant and low-set posteriorly rotated ears. Other features can include short stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay and variable inlectual deficits.
Defects in BRAF are the cause of LEOPARD syndrome type 3 (LEOPARD3) [MIM:613707]. LEOPARD3 is a disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hyperorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness.
Note=A chromosomal aberration involving BRAF is found in pilocytic astrocytomas. A tandem duplication of 2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and inducing cell transformation.
Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 protein kinase domain.
Contains 1 RBD (Ras-binding) domain.
Gene ID:
673
Database links:
Entrez Gene: 673 Human
Entrez Gene: 109880 Mouse
Entrez Gene: 114486 Rat
Omim: 164757 Human
SwissProt: P15056 Human
SwissProt: P28028 Mouse
Unigene: 550061 Human
Unigene: 245513 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
BRAF蛋白是有丝分裂原活化的蛋白激酶/细胞外信号调节激酶途径蛋白。正常的B-Raf蛋白的功能是传递来自细胞膜的信号,在Ras-Raf-MEK-ERK信号转导调节途径中有着重要的作用。
BRAF是一种在癌细胞的生长和存活中起到关键作用的蛋白质,并且在大多数恶性黑素瘤患者和少数结肠癌、乳腺癌和肺癌患者中发生突变,目前BRAF也用于恶性黑素瘤和肿瘤的研究。
人参皂苷Rb1 Ginsenoside Rb1 HPLC≥98% 20mg/支 41753-43-9
人参皂苷Rb2 Ginsenoside Rb2 HPLC≥98% 20mg/支 11021-13-9
人参皂苷Rb3 Ginsenoside Rb3 HPLC≥98% 20mg/支 68406-26-8
人参皂苷Rg1 Ginsenoside Rg1 HPLC≥98% 20mg/支 22427-39-0
人参皂苷Rg2 Ginsenoside Rg2 HPLC≥98% 20mg/支 52286-74-5
人参皂苷Rg3 Ginsenoside Rg3 HPLC≥98% 20mg/支 14197-60-5
人参皂苷Rh1 Ginsenoside Rh1 HPLC≥98% 20mg/支 63223-86-9
人参皂苷Rh2 Ginsenoside Rh2 HPLC≥98% 20mg/支 78214-33-2
拟人参皂苷Rh2 Pseudoginsenoside Rh2 HPLC≥98% 5mg/支 1370264-16-6
人参皂苷Rh3 Ginsenoside Rh3 HPLC≥98% 20mg/支 105558-26-7
人参皂苷Rc Ginsenoside Rc HPLC≥98% 20mg/支 11021-14-0
人参皂苷Re Ginsenoside Re HPLC≥98% 20mg/支 52286-59-6
人参皂苷Rd Ginsenoside Rd HPLC≥98% 20mg/支 52705-93-8
人参皂苷Rf Ginsenoside- Rf HPLC≥98% 20mg/支 52286-58-5
拟人参皂苷RT5 Pseudoginsenoside-RT5 HPLC≥98% 20mg/支 98474-78-3
原人参三醇 Protopanaxatriol HPLC≥98% 20mg/支 34080-08-5
(R型)人参皂苷Rh1 Ginsenoside Rh1 HPLC≥98% 20mg/支
(R型)人参皂苷Rh2 Ginsenoside Rh2 HPLC≥98% 20mg/支 112246-15-8
(R型)人参皂苷Rg2 Ginsenoside Rg2 HPLC≥98% 20mg/支 80952-72-3
(R型)人参皂苷Rg3 Ginsenoside Rg3 HPLC≥98% 20mg/支 38243-03-7
(R型)原人参三醇 Protopanaxtriol HPLC≥98% 20mg/支 1453-93-6
人参皂苷F1 Ginsenoside F1 HPLC≥98% 20mg/支 53963-43-2
人参皂苷F2 Ginsenoside F2 HPLC≥98% 20mg/支 62025-49-4
人参皂苷CK Compound K HPLC≥98% 20mg/支 39262-14-1
(R型)原人参二醇 Protopanaxdiol HPLC≥95% 20mg/支 30636-90-9
人参皂苷Ro Ginsenoside Ro HPLC≥98% 20mg/支 34367-04-9
人参皂苷F3 Ginsenoside F3 HPLC≥98% 10mg/支 62025-50-7
人参皂苷Rg6 Ginsenoside Rg6 HPLC≥98% 20mg/支
人参皂苷Rk1 Ginsenoside Rk1 HPLC≥95% 20mg/支
人参二醇 Panaxadiol HPLC≥98% 20mg/支 19666-76-3
人参三醇 Panaxtriol HPLC≥98% 20mg/支 32791-84-7
原人参二醇 Protopanaxdiol HPLC≥98% 20mg/支 30636-90-9
柴胡皂苷A Saikosaponin A HPLC≥98% 20mg/支 20736-09-8
柴胡皂苷C Saikosaponin C HPLC≥98% 20mg/支 20736-08-7
柴胡皂苷D Saikosaponin D HPLC≥98% 20mg/支 20874-52-6
柴胡皂苷B Saikosaponin B HPLC≥98% 20mg/支
柴胡皂苷B1 Saikosaponin B1 HPLC≥98% 20mg/支 58558-08-0
柴胡皂苷B2 Saikosaponin B2 HPLC≥98% 20mg/支 58316-41-9
三七皂苷R1 Notoginsenoside R1 HPLC≥98% 20mg/支 80418-24-2
三七皂苷Ft1 Notoginsenoside Ft1 HPLC≥98% 20mg/支
三七皂苷R2(R型) 20(S)-Notoginsenoside R2 HPLC≥94.50% 20mg/支
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