田源/转化生长因子β活化激酶1/* Anti-TAK1/MAP3K7

转化生长因子β活化激酶1Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activateAnti-TAK1/MAP3K7
360TIYO.COM-上海田源公司

抗体来源于：（Rabbit）

转化生长因子β活化激酶1的性能参数：

中文名称：转化生长因子β活化激酶1
英文名称：Anti-TAK1/MAP3K7
别名：Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activate
包装号：G2012
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR

转化生长因子β活化激酶1的质量标准:

■交叉反应：	hu, mo, rat, pig, hrs, cow, chk, Rb
■产品类型：	一抗
■应用领域:	/肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 67kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated KLH conjugated synthetic peptide derived from human MAP3K7
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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■■产品介绍：
TAK1 （or MAP3K7） was shown to participate in regulation of transcription by transforming growth factor beta （TGF beta）. TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 （TGF b activated kinase 1） MAPKKK in TGF b signal transduction. TAB1 induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF a activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against TNF a induced NFkB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.

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1mg/1ml转化生长因子β活化激酶1Anti-TAK1/MAP3K7Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activate的相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗