Programmed death-1 (PD-1)是在T细胞上表达的抑制性受体,它能促进炎性T细胞的凋亡并抑制抗炎调节性T细胞的凋亡,从而提高自身耐受性并预防自身免疫性疾病。为了逃避免疫监视,肿瘤细胞经常通过过度表达PD-L1来利用这一系统,PD-L1是一种结合并激活PD-1的配体。抗PD-1单克隆抗体用于阻断PD-L1与PD-1的结合,从而使免疫系统能够发现并杀死肿瘤细胞。
BioXCell提供三种不同克隆号的anti mouse PD-1抗体,分别是: RMP1-14、29F.1A12和J43。
in vivo Antibodies
We have a growing library of 400+ antibodies specifically formulated for in vivo use-validated for purity and quality, readily-available in milligram to gram quantities, and quickly delivered.
Whether you need blocking antibodies against a specific target; functional antibodies or biosimilars to study biological effects; or quality anti-mouse antibodies to increase reproducibility, sensitivity, and specificity, you’ll find monoclonal antibodies (MAbs) for in vivo use that you can rely on.
InVivoPlus anti-mouse PD-1 (CD279)抗体
Catalog #BP0146 Clone:RMP1-14
同种型 | Rat IgG2a, κ |
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InVivoPlus anti-mouse PD-1 (CD279)抗体
Catalog #BP0146 Clone:RMP1-14
推荐的同型对照 | InVivoPlus rat IgG2a isotype control, anti-trinitrophenol |
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Reported Applications | in vivo blocking of PD-1/PD-L signaling |
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