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ALK/p80间变性淋巴瘤激酶（鼠单克隆抗体）

ALK-1

广州健仑生物科技有限公司

间变性大细胞淋巴瘤，即是非霍奇金淋巴瘤的一种独立类型，由德国病理学家Stein等于1985年应用Ki-1（CD30）抗体识别，常呈间变性特征，被命名为间变性大细胞淋巴瘤。REAL分类将B细胞表型者归为弥漫性大B细胞性淋巴瘤。目前，ALCL只包括T表型和Null（非T非B）表型。约60%-85%左右ALCL病例表达间变性淋巴瘤激酶（anaplasticlymphomakinase，ALK）融合蛋白，这是由于2号染色体上的ALK基因位点的畸变所致。zui常见的是t（2；5）（p23；q35）而形成融合基因NPM-ALK，它是由位于5号染色体上的核仁磷酸蛋白B23（NPM）基因与位于2号染色体的ALK基因相融合形成，表达融合蛋白为NPM-ALK蛋白；zui近尚有更多的ALK基因与其他基因通过染色体转位或者是染色体的倒转而形成的融合基因被发现，如t（1；2）（q25；p23）所形成的TPM3-ALK基因，t（2；3）（p23；q21）产生的TFG-ALKs基因，TFG-ALKL基因和TFG-ALKxL基因，inv（2）（p23；q35）所形成的ATIC-ALK基因，t（2；17）（p23；q23）形成的CLTCL-ALK基因及t（X；2）（q11；p23）形成的-ALK基因。

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【产品介绍】

细胞定位：细胞浆

克隆号：ALK-1

同型：IgG3/K

适用组织：石蜡/冰冻

阳性对照：间变性大细胞淋巴瘤

抗原修复：热修复（EDTA）

抗体孵育时间：60min

ALK/p80间变性淋巴瘤激酶（鼠单克隆抗体）ALK-1

临床表现
阿米巴肠病潜伏期长短不一，自1～2周至数月以上不等，虽然患者早已受到溶组织内阿米巴包囊感染，仅以共栖生存，当宿主抵抗力减弱以及肠道内感染等临床上才出现症状。根据临床表现不同，分为以下类型：
1.无症状的带虫者
患者虽然受到溶组织内阿米巴的感染，而阿米巴原虫仅作共栖存在，约有90%以上的人不产生症状而成为包囊携带者。在适当条件下即可侵袭组织，引起病变，出现症状。
2.急性非典型阿米巴肠病
发病较缓慢，无明显全身症状，可有腹部不适，仅有稀便，有时腹泻，每日数次，但缺乏典型的痢疾样粪便，大便检查可发现滋养体。
3.急性典型阿米巴肠病
起病往往缓慢，以腹痛腹泻开始，大便次数逐渐增加，每日可达10～15次之多，便时有不同程度的腹痛与里急后重，后者表示病变已波及直肠。大便带血和黏液，多呈暗红色或紫红色，糊状，具有腥臭味，病情较者可为血便，或白色黏液上覆盖有少许鲜红色血液。患者全身症状一般较轻，在早期体温和白细胞计数可有升高，粪便中可查到滋养体。
4.急性暴发型阿米巴肠病
起病急剧，全身营养状况差，重病容，中毒症状显著，高热，寒战、谵妄、腹痛、里急后重明显，大便为脓血便，有恶臭，亦可呈水样或泔水样便，每日可达20次以上，伴呕吐、虚脱，有不同程度的脱水与电解质紊乱。血液检查中性粒细胞增多。易并发肠出血或甩穿孔，如不及时处理可于1～2周内因毒血症而死亡。
5.慢性迁延型阿米巴肠病
通常为急抗原抗体染的延续，腹泻与便秘交替出现，病程持续数月甚至数年不愈，在间歇期间，可以健康如常。复发常以饮食不当、暴饮暴食、饮酒、受寒、疲劳等为诱因，每日腹泻3～5次，大便呈黄糊状，可查到滋养体或包囊。患者常伴有脐周或下腹部钝痛，有不同程度的贫血、消瘦、营养不良等。

ALK/p80间变性淋巴瘤激酶（鼠单克隆抗体）ALK-1

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

Clinical manifestations
The duration of amoebic enteropathy varies in length, ranging from 1 to 2 weeks to several months, although the patient has been infected with Entamoeba histolytica cysts, surviving only in symbionts, diminishing host resistance, and intestinal infections Clinical symptoms before. According to different clinical manifestations, divided into the following types:
Asymptomatic parasites
Although the patient is infected with Entamoeba histolytica, whereas the amoeba is only present as a concentric, about 90% of people do not develop symptoms and become encapsulated carriers. Inappropriate conditions to attack the organization, causing lesions, symptoms.
Acute atypical amoebic enteropathy
Slow onset, no obvious systemic symptoms, may have abdominal discomfort, only loose stools, sometimes diarrhea, several times a day, but the lack of typical dysentery-like stool, stool examination can be found trophozoites.
Acute typical amoebic enteropathy
The onset is often slow to abdominal pain and diarrhea, stool frequency gradually increased daily up to 10 to 15 times as much, then there are varying degrees of abdominal pain and tenesmus, the latter said the lesion has spread to the rectum. Stool blood and mucus, mostly dark red or purple, paste, with stench, the disease may be more for the blood or white mucus covered with a little red blood. Patients with systemic symptoms generally mild, in the early body temperature and white blood cell count may have increased, feces can be found in trophozoites.
4. Acute outbreak of amoebic enteropathy
Severe onset, poor general nutritional status, severe illness, significant symptoms of poisoning, fever, chills, delirium, abdominal pain, tenesmus and severe stools were pus and blood stools, stench can also be water or watery stool, daily up to 20 Times or more, with vomiting, collapse, there are different degrees of dehydration and electrolyte imbalance. Blood tests for neutrophils. Easily complicated with intestinal bleeding or rejection perforation, if not treated in 1 to 2 weeks due to sepsis and death.
5. Chronic persistent amebic enteropathy
Usually the continuation of the acute antigen antibody staining, alternating diarrhea and constipation, the disease lasted months or even years of unhealed, in the intermittent period, can be as normal. Recurrence often to improper diet, overeating, drinking, cold, fatigue and other incentives, daily diarrhea 3 to 5 times, the stool was yellow paste, can be found trophozoites or cysts. Patients often accompanied by umbilical or lower abdominal dull pain, varying degrees of anemia, weight loss, malnutrition and so on.