Collagen from bovine achilles tendon 胶原蛋白I型说明书 
Product Number: C8060
CAS Number : 9007-34-5
Storage Temperature: 2-8°C
Product Description
This product is suitable for use as a substrate for collagenase. It is prepared by modification of the method of Einbinder
and Schubert and is not suitable for use in coating glassware.
This collagen is Bornstein and Traub Type I. The Type I classification of collagen is a component of skin, bone, tendon,
and other fibrous connective tissues. Type I collagen differs from other collagens by their low lysine hydroxylation
and low carbohydrate composition.
Collagen breaks down metabolically in the body to release N-opeptide, which is the N-terminus of collagen. There
is also C-opeptide, which is presumably the C-terminus. N-opeptide is released in urine, and its detection in
diagnostic tests is used to screen for osteoporosis.
Although different types of collagen exist, they are all composed of molecules containing three polypeptide chains
arranged in a triple helical conformation. Slight differences in the primary structure (amino acid sequence) establish
differences between the types. The amino acid sequence of the primary structure is mainly a repeating motif with
glycine in every third position and proline or 4-hydroxyproline frequently preceeding the glycine residue.
Preparation Instructions
This product is an insoluble collagen preparation. It is insoluble in water, aqueous buffers, dilute acid, and organic
solvents. For use as a substrate in collagenase assays, this collagen can be prepared as a suspension in 50 mM TES
buffer, pH 7.4 with 0.36 mM calcium chloride. but not a clear solution.
Storage/Stability
It is recommended to store this product at 2–8 °C. If stored as recommended, it will have a shelf-life of up to 8 years.
Precautions and Disclaimer
For Laboratory Use Only. Not for drug, household or other uses.
Solarbio
Beijing Solarbio Science & Technology Co., Ltd


Http://www.solarbio-hd。。ｃｎ

胶原蛋白I型说明书

产品数量:C8060

CAS编号:9007-34-5

存储温度:2 - 8°C

产品描述

本产品适用于使用作为胶原酶的底物。它是由Einbinder的修改方法和舒伯特,并不适用于镀膜玻璃器皿。这个胶原蛋白是波恩和特劳布类型一、I型胶原蛋白是皮肤的一个组成部分,分类骨骼,肌腱,

和其他纤维结缔组织。I型胶原蛋白不同于其他胶原蛋白低赖氨酸羟基化和低碳水化合物组成。

胶原蛋白在体内分解代谢释放N-opeptide,胶原蛋白分子的n端。有也是C-opeptide,想必C-terminus。尿液N-opeptide释放,其检测诊断测试筛选用于骨质疏松症。

尽管不同类型的胶原蛋白存在,他们都包含三个多肽链组成的分子

安排在一个三重螺旋构象。轻微的差异(氨基酸序列)建立的主要结构

类型之间的差异。的氨基酸序列一级结构主要是一个重复的主题

在每个第三位置和脯氨酸或甘氨酸4-hydroxyproline经常在甘氨酸残基前夕。

本产品是一种不溶性胶原蛋白制备。它不溶于水,水溶液缓冲区,稀酸和有机的

溶剂。作为基质的胶原酶化验,这种胶原蛋白可以作为悬挂在50 mM的te做好准备

缓冲区,pH值7.4与0.36毫米氯化钙。但不是一个明确的解决方案。

存储/稳定

建议储存该产品在2 - 8°C。如果存储为建议,它将有8年的保质期。

预防措施和免责声明

仅供实验室使用。不是药物,家庭或其他用途。